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KMID : 0858520140180020133
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Journal of the Korean Society of Magnetic Resonance in Medicine
2014 Volume.18 No. 2 p.133 ~ p.143
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Magnetic Resonance Imaging Factors Predicting Re-excision in Breast Cancer Patients Having Undergone Conserving Therapy
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Jang Mi-Jung
Kim Sun-Mi
Yun Bo-La
Kim Sung-Won
Kang Eun-Young
Park So-Yeon
Kim Jee-Hyun
Kim Yeong-Mi
Ahn Hye-Shin
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Abstract
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Purpose: The aim of this study was to determine the magnetic resonance imaging (MRI) features associated with re-excision due to the presence of a positive margin after breast conserving therapy (BCT) in breast cancer patients.
Materials and Methods: We reviewed the records of 286 consecutive breast cancer patients who received BCT between January 2006 and December 2007. Among 246 patients who had undergone BCT, 38 (15.4%) underwent immediate further surgery due to positive margin status. We analyzed the MRI findings using χ2 test, Fisher's exact test and t tests. Multivariate logistic regression was conducted for prediction of re-excision.
Results: Tumor size (p < 0.001), lesion multiplicity (p = 0.003), and non-mass-like enhancement (NMLE) type on MRI (p < 0.001) were associated with margin involvement in BCT. On preoperative MRI, larger size (≥ 5 cm) (odds ratio = 2.96), NMLE (odds ratio = 3.81), and multifocal lesions (odds ratio = 2.54) were positively associated with re-excision. In cases involving NMLE, segmental distribution was associated with a greater likelihood of immediate re-excision.
Conclusion: Larger size, multiplicity, and NMLE on MRI are significantly associated with re-excision after BCT in breast cancer patients. For NMLE lesions, the segmental distribution pattern was predictive of re-excision.
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KEYWORD
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Breast, Breast neoplasm, Conservation therapy, Diagnosis, Magnetic resonance imaging (MRI)
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